Article
Cardiovascular and renal phenotyping of genetically modified mice: a challenge for traditional physiology.
Clinical and experimental pharmacology & physiology - 1 Apr 2003
Fitzgerald Sharyn M, Gan Liming, Wickman Anna, Bergström Göran
Abstract excerpt
1. The advent of techniques to genetically modify experimental animals and produce directed mutations in both a conditional and tissue-specific manner has dramatically opened up new fields for physiologists in cardiovascular and renal research. 2. A consequence of altering the genetic background of mice is the difficulty in predicting the phenotypic outcome of the genetic mutation. We therefore suggest that...
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