Article
dMi-2, a hunchback-interacting protein that functions in polycomb repression.
Science (New York, N.Y.) - 4 Dec 1998
Kehle J, Beuchle D, Treuheit S, Christen B, Kennison J A, Bienz M, Müller J
Abstract excerpt
Early in Drosophila embryogenesis, gap gene products directly repress transcription of homeotic (HOX) genes and thereby delimit HOX expression domains. Subsequently, Polycomb-group proteins maintain this repression. Currently, there is no known molecular link between gap and Polycomb-group proteins. Here, dMi-2 is identified as a protein that binds to a domain in the gap protein Hunchback that is specifically...
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