Article
Host genetic determinants of vaccine-induced eosinophilia during respiratory syncytial virus infection.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1998
Hussell T, Georgiou A, Sparer T E, Matthews S, Pala P, Openshaw P J
Abstract excerpt
In BALB/c mice, sensitization with the attachment protein (G) of respiratory syncytial virus (RSV) leads to CD4+ T cell-mediated lung eosinophilia during subsequent challenge with RSV. To determine the host genetic influences on this model of lung eosinophilia, we tested 15 different inbred mouse...
Topics
- Animals
- Antibodies, Viral
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Crosses, Genetic
- Cytokines
- Eosinophilia
- Female
- Genetic Predisposition to Disease
- H-2 Antigens
- HN Protein
- Immunity, Innate
- Intracellular Fluid
- Lymphocyte Depletion
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred C57BL