Article
Immune responses to the nonglycosylated ectodomain of respiratory syncytial virus attachment glycoprotein mediate pulmonary eosinophilia in inbred strains of mice with different MHC haplotypes.
Journal of medical virology - 1 Jun 2003
Hancock Gerald E, Tebbey Paul W, Scheuer Catherine A, Pryharski Karin S, Heers Kristen M, LaPierre Natisha A
Abstract excerpt
Development of subunit vaccines against respiratory syncytial virus (RSV) for naive human infants is hindered by concerns that immunization with the fusion or attachment (G) proteins will elicit polarized Type 2 T cell responses and cause immunopotentiation upon subsequent natural infection. We investigated the regions of G protein responsible for inducing a Type 2 T cell phenotype in inbred mice of different MHC...
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