Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing <i>Cre</i> recombinase exclusively in eosinophils

Abstract excerpt

Eosinophils are generally linked to innate host defense against helminths, as well as the pathologies associated with allergic diseases, such as asthma. Nonetheless, the activities of eosinophils remain poorly understood, which in turn, has prevented detailed definitions of their role(s) in health and disease. Homologous recombination in embryonic stem cells was used to insert a mammalianized Cre recombinase in...

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