Article
Opposite regulation of tyrosine-phosphorylation of p130(Cas) by insulin and insulin-like growth factor I.
Journal of biochemistry - 1 Dec 1998
Fujita T, Maegawa H, Kashiwagi A, Hirai H, Kikkawa R
Abstract excerpt
To investigate the difference in signaling between insulin and insulin-like growth factor I (IGF-I), we studied the effects of these hormones on the phosphorylation state of Crk-associated substrate (Cas) in cells expressing human insulin receptor (HIRc). In the basal state, Cas was heavily tyros...
Topics
- Animals
- Binding Sites
- Cells, Cultured
- Fibroblasts
- Glutathione Transferase
- Humans
- Insulin
- Insulin-Like Growth Factor I
- Intracellular Signaling Peptides and Proteins
- Mutation
- Phosphorylation
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-cbl
- Rats
- Receptor, Insulin