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Article

Opposite regulation of tyrosine-phosphorylation of p130(Cas) by insulin and insulin-like growth factor I.

Journal of biochemistry - 1 Dec 1998

Fujita T, Maegawa H, Kashiwagi A, Hirai H, Kikkawa R

Abstract excerpt

To investigate the difference in signaling between insulin and insulin-like growth factor I (IGF-I), we studied the effects of these hormones on the phosphorylation state of Crk-associated substrate (Cas) in cells expressing human insulin receptor (HIRc). In the basal state, Cas was heavily tyrosine-phosphorylated, and insulin dephosphorylated Cas in a time- and dose-dependent manner. On the other hand, IGF-I...

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PMID: 9832615
DOI: 10.1093/oxfordjournals.jbchem.a022228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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