Article
Insulin activation of mitogen-activated protein kinases Erk1,2 is amplified via beta-adrenergic receptor expression and requires the integrity of the Tyr350 of the receptor.
The Journal of biological chemistry - 17 Nov 2000
Wang H y, Doronin S, Malbon C C
Abstract excerpt
Insulin activates a complex set of intracellular responses, including the activation of mitogen-activated protein kinases Erk1,2. The counterregulatory actions of insulin on catecholamine action are well known and include phosphorylation of the beta(2)-adrenergic receptor on Tyr(350), Tyr(354), and Tyr(364) in the C-terminal cytoplasmic domain, as well as enhanced sequestration of the beta(2)-adrenergic receptor....
Topics
- Adrenergic beta-Agonists
- Animals
- CHO Cells
- Chromones
- Cricetinae
- Dose-Response Relationship, Drug
- Enzyme Activation
- Fluorescent Antibody Technique
- Gene Expression Regulation
- Humans
- Insulin
- Isoproterenol
- Microscopy, Fluorescence