Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

doi:10.1073/pnas.92.3.664

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Article

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 1995

Yamauchi K, Milarski K L, Saltiel A R, Pessin J E

Abstract excerpt

SHPTP2 is a ubiquitously expressed tyrosine-specific protein phosphatase that contains two amino-terminal Src homology 2 (SH2) domains responsible for its association with tyrosine-phosphorylated proteins. In this study, expression of dominant interfering mutants of SHPTP2 was found to inhibit insulin stimulation of c-fos reporter gene expression and activation of the 42-kDa (Erk2) and 44-kDa (Erk1)...

Topics

Adaptor Proteins, Signal Transducing
Animals
CHO Cells
Calcium-Calmodulin-Dependent Protein Kinases
Cell Adhesion Molecules
Cell Extracts
Cricetinae
DNA, Complementary
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

GRB2 Adaptor Protein

Genes, Reporter

Genes, fos

Insulin

Intracellular Signaling Peptides and Proteins

Mitogen-Activated Protein Kinase 1

Mitogen-Activated Protein Kinase 3

Mitogen-Activated Protein Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 7531337
DOI: 10.1073/pnas.92.3.664
PMCID: PMC42680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7531337-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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