Article
Regulation of the immunoglobulin heavy chain locus expression at the phylogenetic level of a bony fish: transcription factor interaction with two variant octamer motifs.
Gene - 1 Aug 2006
Hikima Jun-Ichi, Lennard Mara L, Wilson Melanie R, Miller Norman W, Warr Gregory W
Abstract excerpt
Transcriptional control of the IGH locus in teleosts is not fully understood, but evidence from catfish and zebrafish indicates major roles for octamer-binding (Oct) and E-protein transcription factors. A pair of variant octamer motifs in the Emu3' enhancer of the catfish has been shown to be particularly important in driving expression, justifying detailed study of their function. These octamer motifs were...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- DNA
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Genes, Immunoglobulin
- Genes, Reporter
- Genetic Variation
- Ictaluridae
- Immunoglobulin Heavy Chains
- Models, Biological
- Nucleic Acid Conformation