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Article

Expression of liver X receptor beta is essential for formation of superficial cortical layers and migration of later-born neurons.

Proceedings of the National Academy of Sciences of the United States of America - 9 Sept 2008

Fan Xiaotang, Kim Hyun-Jin, Bouton Didier, Warner Margaret, Gustafsson Jan-Ake

Abstract excerpt

Liver X receptor (LXR) beta regulates cholesterol levels in the brain and is essential for maintenance of motor neurons in the spinal cord and dopaminergic neurons in the substantia nigra. Here, we have examined the expression pattern of LXRbeta protein in the cerebral cortex and looked for defects in cortical development in LXRbeta knockout (LXRbeta(-/-)) mice. LXRbeta protein was widely expressed in the mouse...

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Identifiers

PMID: 18768805
DOI: 10.1073/pnas.0806974105
PMCID: PMC2533209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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