Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immediate and delayed effects of E-cadherin inhibition on gene regulation and cell motility in human epidermoid carcinoma cells.

Molecular and cellular biology - 1 Oct 2005

Andersen Henriette, Mejlvang Jakob, Mahmood Shaukat, Gromova Irina, Gromov Pavel, Lukanidin Eugene, Kriajevska Marina, Mellon J Kilian, Tulchinsky Eugene

Abstract excerpt

The invasion suppressor protein, E-cadherin, plays a central role in epithelial cell-cell adhesion. Loss of E-cadherin expression or function in various tumors of epithelial origin is associated with a more invasive phenotype. In this study, by expressing a dominant-negative mutant of E-cadherin (Ec1WVM) in A431 cells, we demonstrated that specific inhibition of E-cadherin-dependent cell-cell adhesion led to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadherins
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Adhesion

Share to Cell Movement

Share to DNA, Neoplasm

Share to ErbB Receptors

Share to RNA Interference

Share to Transcription Factor AP-1

Source

Open in PubMed Open full text

Identifiers

PMID: 16199889
DOI: 10.1128/MCB.25.20.9138-9150.2005
PMCID: PMC1265771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immediate and delayed effects of E-cadherin inhibition on gene regulation and cell motility in human epidermoid carcinoma cells.PMID 16199889Read ↗

Epithelial-Mesenchymal Transitions in Cancer ProgressionSemantic proximity Read ↗

The C terminus of E1A regulates tumor progression and epithelial cell differentiation.Semantic proximity Read ↗

Dynamics of cell adhesion and motility in living cells is altered by a single amino acid change in E-cadherin fused to enhanced green fluorescent protein.Semantic proximity Read ↗

E-cadherin promotor methylation and mutation are inversely related to motility capacity of breast cancer cells.Semantic proximity Read ↗

Characterization of E-cadherin-dependent and -independent events in a new model of c-Fos-mediated epithelial-mesenchymal transition.Semantic proximity Read ↗

Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state.Semantic proximity Read ↗

Identification of a novel mechanism of regulation of the adherens junction by E1A, Rac1, and cortical actin filaments that contributes to tumor progression.Semantic proximity Read ↗

E1a induces the expression of epithelial characteristics.Semantic proximity Read ↗

FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma.Semantic proximity Read ↗

Loss of E-cadherin promotes prostate cancer metastasis via upregulation of metastasis-associated gene 1 expressionSemantic proximity Read ↗

EpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growthSemantic proximity Read ↗

The cytoplasmic domain of N-cadherin modulates MMP‑9 induction in oral squamous carcinoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.