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Article

40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling.

Nature communications - 20 May 2021

Young David J, Meydan Sezen, Guydosh Nicholas R

Abstract excerpt

The recycling of ribosomes at stop codons for use in further rounds of translation is critical for efficient protein synthesis. Removal of the 60S subunit is catalyzed by the ATPase Rli1 (ABCE1) while removal of the 40S is thought to require Tma64 (eIF2D), Tma20 (MCT-1), and Tma22 (DENR). However, it remains unclear how these Tma proteins cause 40S removal and control reinitiation of downstream translation. Here...

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Identifiers

PMID: 34016977
DOI: 10.1038/s41467-021-23223-8
PMCID: PMC8137927

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