Article
DNA adducts in human breast tissue: association with N-acetyltransferase-2 (NAT2) and NAT1 genotypes.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 1998
Pfau W, Stone E M, Brockstedt U, Carmichael P L, Marquardt H, Phillips D H
Abstract excerpt
The etiology of human breast cancer is poorly understood, but circumstantial evidence points toward exogenous genotoxins as causative agents; they are believed to exert their carcinogenic action by binding to DNA. Because this binding is often preceded by metabolic activation, it is dependent on...
Topics
- Adolescent
- Adult
- Aged
- Arylamine N-Acetyltransferase
- Breast
- Breast Neoplasms
- Chromatography, High Pressure Liquid
- DNA Adducts
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Middle Aged
- Pilot Projects