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Article

DNA adducts in human breast tissue: association with N-acetyltransferase-2 (NAT2) and NAT1 genotypes.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 1998

Pfau W, Stone E M, Brockstedt U, Carmichael P L, Marquardt H, Phillips D H

Abstract excerpt

The etiology of human breast cancer is poorly understood, but circumstantial evidence points toward exogenous genotoxins as causative agents; they are believed to exert their carcinogenic action by binding to DNA. Because this binding is often preceded by metabolic activation, it is dependent on the expression and activities of metabolic enzymes of the host. Human mammary tissue samples from 42 women undergoing...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9829711

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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DNA adducts in human breast tissue: association with N-acetyltransferase-2 (NAT2) and NAT1 genotypes.PMID 9829711Read ↗

Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancer.Semantic proximity Read ↗

A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer.Semantic proximity Read ↗

N-acetyltransferase 2 (NAT2) genotypes, cigarette smoking, and the risk of breast cancer.Semantic proximity Read ↗

Genetic analysis of the arylamine N-acetyltransferase polymorphism in breast cancer patients.Semantic proximity Read ↗

A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer.Semantic proximity Read ↗

Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk.Semantic proximity Read ↗

NAT2 slow acetylator genotype as an important modifier of breast cancer risk.Semantic proximity Read ↗

Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.Semantic proximity Read ↗

NATb/NAT1*4 promotes greater arylamine N-acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4-aminobiphenyl.Semantic proximity Read ↗

Cigarette smoking, N-acetyltransferases 1 and 2, and breast cancer risk.Semantic proximity Read ↗

N-Acetyltransferase-2 genetic polymorphism, well-done meat intake, and breast cancer risk among postmenopausal women.Semantic proximity Read ↗

N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast.Semantic proximity Read ↗

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