Article
Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk.
JAMA - 13 Nov 1996
Ambrosone C B, Freudenheim J L, Graham S, Marshall J R, Vena J E, Brasure J R, Michalek A M, Laughlin R, Nemoto T, Gillenwater K A, Shields P G
Abstract excerpt
OBJECTIVE: To determine if N-acetyltransferase 2 (NAT2) polymorphisms result in decreased capacity to detoxify carcinogenic aromatic amines in cigarette smoke, thus making some women who smoke more susceptible to breast cancer. DESIGN: Case-control study with genetic analyses. DNA analyses were performed for 3 polymorphisms accounting for 90% to 95% of the slow acetylation phenotype among whites. SETTING AND...
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