Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk.

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Article

Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk.

JAMA - 13 Nov 1996

Ambrosone C B, Freudenheim J L, Graham S, Marshall J R, Vena J E, Brasure J R, Michalek A M, Laughlin R, Nemoto T, Gillenwater K A, Shields P G

Abstract excerpt

OBJECTIVE: To determine if N-acetyltransferase 2 (NAT2) polymorphisms result in decreased capacity to detoxify carcinogenic aromatic amines in cigarette smoke, thus making some women who smoke more susceptible to breast cancer. DESIGN: Case-control study with genetic analyses. DNA analyses were p...

Topics

Adult
Aged
Arylamine N-Acetyltransferase
Breast Neoplasms
Case-Control Studies
DNA
Female
Genotype
Humans
Middle Aged
Plants, Toxic
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Postmenopause

Premenopause

Risk Assessment

Risk Factors

Smoke

Smoking

Source

Open in PubMed

Identifiers

PMID: 8903261

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8903261-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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