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Article

N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast.

Pharmacogenetics - 1 Jul 2001

Williams J A, Stone E M, Fakis G, Johnson N, Cordell J A, Meinl W, Glatt H, Sim E, Phillips D H

Abstract excerpt

Heterocyclic amines are mammary carcinogens in rats and their N-hydroxy metabolites are substrates for subsequent metabolic activation by N-acetyltransferases (NAT) and sulfotransferases (SULT) in man. We investigated the expression of these enzymes in human breast tissue and the relationship between NAT genotype and NAT mRNA expression or enzyme activity. Immunohistochemical staining of sections of breast tissue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11470991
DOI: 10.1097/00008571-200107000-00002

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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