Article
p53 isoform profiling in glioblastoma and injured brain.
Oncogene - 27 Jun 2013
Takahashi R, Giannini C, Sarkaria J N, Schroeder M, Rogers J, Mastroeni D, Scrable H
Abstract excerpt
The tumor suppressor p53 has been found to be the most commonly mutated gene in human cancers; however, the frequency of p53 mutations varies from 10 to 70% across different cancer types. This variability can partly be explained by inactivating mechanisms aside from direct genomic polymorphisms. The p53 gene encodes 12 isoforms, some of which can modulate full-length p53 activity in cancer. In this study, we...
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