Article
TP53 gene in blood plasma DNA of tumor patients.
Annals of the New York Academy of Sciences - 1 Jun 2004
Schlechte Horst H, Stelzer Cornelia, Weickmann Sabine, Fleischhacker Michael, Schulze Guntram
Abstract excerpt
Tumor-specific TP53 mutations are detectable in the blood plasma of tumor patients. Mutations of the TP53 tumor suppressor gene are risk factors for tumor progression. The objective of this work is to compare the presence of TP53 mutations in plasma-DNA before and after tumor treatment with the status of this gene in the tumor tissue sample. DNA was extracted from plasma samples of 25 patients with...
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