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Article

Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen Dby.

The Journal of clinical investigation - 1 Jun 2004

Chen Tse-Ching, Waldmann Herman, Fairchild Paul J

Abstract excerpt

T cell reactivity to minor histocompatibility (mH) antigens is responsible for rejection of HLA-matched allografts, limiting the effectiveness of transplantation for the treatment of end-stage organ failure. The deadbox gene Dby is located on the Y chromosome and encodes an mH antigen that prompts rejection of male tissues by female mice. Establishing a network of regulatory T (T(reg)) cells that is capable of...

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Share to DEAD-box RNA Helicases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Lymphocyte Activation

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Source

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Identifiers

PMID: 15199410
DOI: 10.1172/JCI20569
PMCID: PMC420506

Genes

RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen Dby.PMID 15199410Read ↗

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