Article
Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping.
Pharmacogenetics - 1 Oct 1998
Kashuba A D, Nafziger A N, Kearns G L, Leeder J S, Shirey C S, Gotschall R, Gaedigk A, Bertino J S
Abstract excerpt
Intraindividual variability and the effects of menstrual cycle phase on CYP2D6 activity were evaluated by dextromethorphan phenotyping in 20 Caucasian normal volunteers. Dextromethorphan 30 mg was administered to 10 men every 14 days for 3 months, and to 10 premenopausal women during the mid-foll...
Topics
- Adult
- Analysis of Variance
- Cytochrome P-450 CYP2D6
- Dextromethorphan
- Dextrorphan
- Female
- Follicular Phase
- Genotype
- Humans
- Luteal Phase
- Male
- Menstrual Cycle
- Middle Aged
- Phenotype
- Sex Factors
- White People