Article
Lack of gender differences and large intrasubject variability in cytochrome P450 activity measured by phenotyping with dextromethorphan.
Journal of clinical pharmacology - 1 Jul 2001
McCune J S, Lindley C, Decker J L, Williamson K M, Meadowcroft A M, Graff D, Sawyer W T, Blough D K, Pieper J A
Abstract excerpt
Gender-based differences in cytochrome P450 (CYP) activity may occur due to endogenous hormonal fluctuations with the menstrual cycle, which are altered by oral contraceptives. This study assessed the average activity and within-subject variability in CYP3A4 and CYP2D6 in men, women taking Triphasil, and regularly menstruating women not receiving oral contraceptives. Thirty-three healthy volunteers participated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.