Quantification of 3-month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam.

doi:10.1016/S0009-9236(98)90175-8

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Article

Quantification of 3-month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam.

Clinical pharmacology and therapeutics - 1 Sept 1998

Kashuba A D, Bertino J S, Rocci M L, Kulawy R W, Beck D J, Nafziger A N

Abstract excerpt

OBJECTIVE: Intraindividual variability and the effects of sex and menstrual cycle phase on CYP3A activity were evaluated by phenotyping with use of midazolam as the probe drug. METHODS: Midazolam (0.025 mg/kg) was administered intravenously to 10 white male volunteers every 14 days for 3 months a...

Topics

Adult
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
Female
Follicular Phase
Humans
Hydroxylation
Hypnotics and Sedatives
Infusions, Intravenous
Luteal Phase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Menstrual Cycle

Midazolam

Middle Aged

Oxidoreductases, N-Demethylating

Phenotype

Reference Values

Source

Open in PubMed

Identifiers

PMID: 9757150
DOI: 10.1016/S0009-9236(98)90175-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9757150-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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