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Article

Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity.

Pharmacogenetics - 1 Aug 1999

Kashuba A D, Nafziger A N, Kearns G L, Leeder J S, Gotschall R, Gaedigk A, Bertino J S

Abstract excerpt

We evaluated the utility of the 3-methoxymorphinan/dextromethorphan (3MM/DM) urinary ratio to reflect baseline CYP3A activity, and its ability to discriminate moderate CYP3A inhibition during fluvoxamine therapy. For 4 months, oral dextromethorphan 30 mg and intravenous midazolam 0.025 mg/kg were administered to nine men every 14 days, and to 10 premenopausal women during the follicular and luteal phases of their...

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PMID: 10780265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity.PMID 10780265Read ↗

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