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Article

Impact of Pregnancy and Vitamin A Supplementation on CYP2D6 Activity.

Journal of clinical pharmacology - 1 Mar 2023

Amaeze Ogochukwu U, Czuba Lindsay C, Yadav Aprajita S, Fay Emily E, LaFrance Jeffrey, Shum Sara, Moreni Sue L, Mao Jennie, Huang Weize, Isoherranen Nina, Hebert Mary F

Abstract excerpt

The mechanism of cytochrome P450 2D6 (CYP2D6) induction during pregnancy has not been evaluated in humans. This study assessed the changes in CYP2D6 and CYP3A activities during pregnancy and postpartum, and the effect of vitamin A administration on CYP2D6 activity. Forty-seven pregnant CYP2D6 extensive metabolizers (with CYP2D6 activity scores of 1 to 2) received dextromethorphan (DM) 30 mg orally as a single...

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Share to Cytochrome P-450 CYP2D6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36309846
DOI: 10.1002/jcph.2169
PMCID: PMC9931631

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