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Article

Evidence for a link between iron metabolism and Nramp1 gene function in innate resistance against Mycobacterium avium.

Immunology - 1 Oct 1998

Gomes M S, Appelberg R

Abstract excerpt

In the mouse, the progression of the Mycobacterium avium infection is highly dependent on the Nramp1 gene. Strains of mice that express the Nramp1D169 allele are highly susceptible to M. avium infections, while Nramp1G169 strains of mice can control them. Recently, the Nramp1 gene has been cloned and characterized as coding a transmembrane protein, probably involved in divalent cation transport. One possible...

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Identifiers

PMID: 9824471
DOI: 10.1046/j.1365-2567.1998.00630.x
PMCID: PMC1364300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Evidence for a link between iron metabolism and Nramp1 gene function in innate resistance against Mycobacterium avium.PMID 9824471Read ↗

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Structure and function of the natural-resistance-associated macrophage protein (Nramp1), a candidate protein for infectious and autoimmune disease susceptibility.Semantic proximity Read ↗

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Nramp1 locus encodes a 65 kDa interferon-γ-inducible protein in murine macrophagesSemantic proximity Read ↗

Natural resistance to intracellular pathogens: modulation of macrophage signal transduction related to the expression of the Bcg locus.Semantic proximity Read ↗

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Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg).Semantic proximity Read ↗

Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains.Semantic proximity Read ↗

Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story.Semantic proximity Read ↗

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