Evidence for a link between iron metabolism and Nramp1 gene function in innate resistance against Mycobacterium avium.

doi:10.1046/j.1365-2567.1998.00630.x

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Article

Evidence for a link between iron metabolism and Nramp1 gene function in innate resistance against Mycobacterium avium.

Immunology - 1 Oct 1998

Gomes M S, Appelberg R

Abstract excerpt

In the mouse, the progression of the Mycobacterium avium infection is highly dependent on the Nramp1 gene. Strains of mice that express the Nramp1D169 allele are highly susceptible to M. avium infections, while Nramp1G169 strains of mice can control them. Recently, the Nramp1 gene has been cloned...

Topics

Alleles
Animals
Biological Transport
Carrier Proteins
Cation Transport Proteins
Gene Expression
Immunity, Innate
Iron
Iron-Dextran Complex
Liver
Macrophages
Membrane Proteins
Mice
Mice, Congenic
Mice, Inbred BALB C
Mycobacterium Infections
Mycobacterium avium

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