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Article

Nuclear hormone receptor regulation of PAL-1/Caudal mediates ventral nerve cord assembly in C. elegans.

Developmental biology - 1 Dec 2025

Noblett Nathaniel, Roenspies Tony, Flibotte Stephane, Colavita Antonio

Abstract excerpt

The regulatory network governed by CDX/Caudal family transcription factors plays critical roles in shaping embryonic neural development. In C. elegans, we found that proper expression of pal-1, the C. elegans Caudal homologue, is required for correct positioning of motor neuron cell bodies in the first larval stage ventral nerve cord (VNC). We identified an upstream regulatory region within the pal-1 promoter...

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PMID: 40902841
DOI: 10.1016/j.ydbio.2025.08.023

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