The evolution of nematode sex determination: C. elegans as a reference point for comparative biology

Abstract excerpt

Sex determination was a founding topic of C. elegans research. After three decades of research, a complex signal transduction pathway with multiple layers of regulation has been elucidated. This pathway links karyotype to phenotype by coordinating the development of sexually dimorphic tissues. In this article, this pathway is placed in two broader contexts. The first is that of nematodes and animals in general....

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