Article
The difference in p53 mutations between cancers of the upper and lower gastrointestinal tract.
Digestion - 1 Jan 2009
Oki Eiji, Zhao Yan, Yoshida Rintaro, Egashira Akinori, Ohgaki Kippei, Morita Masaru, Kakeji Yoshihiro, Maehara Yoshihiko
Abstract excerpt
BACKGROUND: p53 gene mutations have been reported in over half of all human cancers and they appear to occur in the early stage of cancer, thus indicating the important role that such mutations may play in the carcinogenesis of the digestive tract. This study investigated the differences in p53 abnormalities between cancers of the upper and lower gastrointestinal tract. MATERIALS AND METHODS: The DNA of 354...
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