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Article

Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene.

Oncogene - 3 Feb 2000

Tolkacheva T, Chan A M

Abstract excerpt

The human PTEN/MMAC1/TEP1 (PTEN) tumor suppressor gene encodes a phosphatase with specificity towards the D3 phosphate of phosphatidylinositides. PTEN mutations have been reported in the endometrioid type of uterine tumors which are associated with frequent activations of the Ras oncogenes. In this study, we report the ability of PTEN to potently inhibit H-Ras induced morphological transformation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10698513
DOI: 10.1038/sj.onc.1203331

Genes

PTEN
TEP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The biology and clinical relevance of the PTEN tumor suppressor pathway.Semantic proximity Read ↗

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