Article
Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.
Oncogene - 4 Apr 2002
Koul Dimpy, Jasser Samar A, Lu Yiling, Davies Michael A, Shen Ruijun, Shi Yuexi, Mills Gordon B, Yung W K Alfred
Abstract excerpt
The tumor suppressor gene, MMAC/PTEN, has phosphatase, C2, and PDZ-binding domains as well as potential sites of regulation by phosphorylation, including tyrosine phosphorylation, which may contribute to its ability to modulate cell growth and viability. Several obvious and significant motifs were found in MMAC/PTEN, including most notably, a catalytic domain of tyrosine phosphatase (IHCxxGxxRS/T) and several...
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