Article
Involvement of cell surface glycosyl-phosphatidylinositol-linked aspartyl proteases in alpha-secretase-type cleavage and ectodomain solubilization of human Alzheimer beta-amyloid precursor protein in yeast.
The Journal of biological chemistry - 27 Nov 1998
Komano H, Seeger M, Gandy S, Wang G T, Krafft G A, Fuller R S
Abstract excerpt
Human beta-amyloid precursor protein (APP) introduced into yeast undergoes alpha-secretase-type cleavage, suggesting that yeast have alpha-secretase-like protease(s). Here we report that two structurally and functionally related glycosyl-phosphatidylinositol-linked yeast aspartyl proteases, Mkc7p...
Topics
- Amyloid Precursor Protein Secretases
- Amyloid beta-Protein Precursor
- Aspartic Acid Endopeptidases
- Cell Membrane
- Cloning, Molecular
- Endopeptidases
- Genotype
- Humans
- Mutagenesis, Site-Directed
- Plasmids
- Protein Processing, Post-Translational
- Recombinant Proteins
- Saccharomyces cerevisiae