Article
Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions.
The Journal of biological chemistry - 13 Jan 2006
Albrecht Antje, Felk Angelika, Pichova Iva, Naglik Julian R, Schaller Martin, de Groot Piet, Maccallum Donna, Odds Frank C, Schäfer Wilhelm, Klis Frans, Monod Michel, Hube Bernhard
Abstract excerpt
Intracellular and secreted proteases fulfill multiple functions in microorganisms. In pathogenic microorganisms extracellular proteases may be adapted to interactions with host cells. Here we describe two cell surface-associated aspartic proteases, Sap9 and Sap10, which have structural similarities to yapsins of Saccharomyces cerevisiae and are produced by the human pathogenic yeast Candida albicans. Sap9 and...
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