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Article

In vitro reconstitution of gamma-secretase activity using yeast microsomes.

Biochemical and biophysical research communications - 5 Dec 2008

Yagishita Sosuke, Futai Eugene, Ishiura Shoichi

Abstract excerpt

gamma-Secretase is composed of at least four transmembrane proteins, presenilin (PS) 1/2, nicastrin, anterior pharynx-1 (Aph-1) and presenilin enhancer-2 (Pen-2), and cleaves amyloid precursor protein (APP) to produce amyloid beta peptides (Abeta) that is deposited in the brains of Alzheimer disease. However, the mechanism of gamma-secretase-mediated cleavage remains unclear. To examine the enzymatic properties...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18834861
DOI: 10.1016/j.bbrc.2008.09.090

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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