Article
Genes other than TLR4 are involved in the response to inhaled LPS.
American journal of physiology. Lung cellular and molecular physiology - 1 Nov 2001
Lorenz E, Jones M, Wohlford-Lenane C, Meyer N, Frees K L, Arbour N C, Schwartz D A
Abstract excerpt
For several decades, the mouse strains C3H/HeJ and C57BL/10ScNCr have been known to be hyporesponsive to endotoxin or lipopolysaccharide (LPS). Recently, mutations in Toll-like receptor (TLR) 4 have been shown to underlie this aberrant response to LPS. To further determine the relationship between TLR4 and responsiveness to LPS, we genotyped 18 strains of mice for TLR4 and evaluated the physiological and...
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