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Article

Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation.

Molecular pain - 28 May 2009

Romero-Sandoval Edgar Alfonso, Horvath Ryan, Landry Russell P, DeLeo Joyce A

Abstract excerpt

BACKGROUND: Cannabinoid receptor type 2 (CBR2) inhibits microglial reactivity through a molecular mechanism yet to be elucidated. We hypothesized that CBR2 activation induces an anti-inflammatory phenotype in microglia by inhibiting extracellular signal-regulated kinase (ERK) pathway, via mitogen...

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Share to Animals, Newborn
Share to Extracellular Signal-Regulated MAP Kinases
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Rats, Sprague-Dawley

Share to Receptor, Cannabinoid, CB2

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Source

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Identifiers

PMID: 19476641
DOI: 10.1186/1744-8069-5-25
PMCID: PMC2704199

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19476641-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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