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Article

Defective ceramide response in C3H/HeJ (Lpsd) macrophages.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1995

Barber S A, Perera P Y, Vogel S N

Abstract excerpt

Lipid second messengers are gaining recognition as important mediators of extracellular signals. One such lipid, ceramide, generated from membrane sphingomyelin following stimulation with TNF-alpha, IL-1 beta, or IFN-gamma, activates ceramide-activated kinase (CAK). A recent study demonstrated that LPS activated CAK without generating ceramide, suggesting that the LPS stimulation of cells mimics the second...

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PMID: 7650365

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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