Article
LPS-hyporesponsiveness of mnd mice is associated with a mutation in Toll-like receptor 4.
Genes and immunity - 1 Feb 2001
Bihl F, Larivière L, Qureshi S T, Flaherty L, Malo D
Abstract excerpt
Toll-like receptors (Tlrs) are transmembrane proteins that have recently been shown to play a critical role in the innate immune recognition of microbial constituents. Among this family, Tlr4 is a crucial signal transducer for lipopolysaccharide (LPS), the major component of the Gram-negative bacteria outer cell membrane. In this paper, we report that C57BL/6.KB2-mnd mice, a model of neuronal ceroid...
Topics
- Animals
- Base Sequence
- DNA Primers
- Drosophila Proteins
- Lipopolysaccharides
- Membrane Glycoproteins
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutation
- Neuronal Ceroid-Lipofuscinoses
- Phenotype
- Receptors, Cell Surface
- Toll-Like Receptor 4
- Toll-Like Receptors