Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Correlation between genotype and phenotype of the human arylamine N-acetyltransferase type 1 (NAT1).

Biochemical pharmacology - 1 Dec 1999

Bruhn C, Brockmöller J, Cascorbi I, Roots I, Borchert H H

Abstract excerpt

Arylamine N-acetyltransferase 1 (NAT1) conjugates several aromatic amines and their N-hydroxylated metabolites by N- or O-acetylation. NAT1 genotype and phenotype is known to be variable in human populations. In this study, we set out to measure the functional relevance of the frequent NAT1 gene variants for the activity in human red blood cells. Healthy German volunteers (N = 314) were genotyped for NAT1 alleles...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 4-Aminobenzoic Acid
Share to Arylamine N-Acetyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Erythrocytes

Share to Genotype

Share to Isoenzymes

Share to Kinetics

Share to Polymorphism, Genetic

Share to Substrate Specificity

Source

Identifiers

PMID: 10571250
DOI: 10.1016/s0006-2952(99)00269-5

Genes

NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Correlation between genotype and phenotype of the human arylamine N-acetyltransferase type 1 (NAT1).PMID 10571250Read ↗

Human acetyltransferase polymorphisms.Semantic proximity Read ↗

Genotyping human arylamine N-acetyltransferase type 1 (NAT1): the identification of two novel allelic variants.Semantic proximity Read ↗

N-Acetyltransferase-1 gene polymorphisms and correlation between genotype and its activity in a central Chinese Han population.Semantic proximity Read ↗

Regulation of the activity of the human drug metabolizing enzyme arylamine N-acetyltransferase 1: role of genetic and non genetic factors.Semantic proximity Read ↗

Polymorphism of N-acetyltransferase 1 and correlation between genotype and phenotype in a Thai population.Semantic proximity Read ↗

Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations.Semantic proximity Read ↗

Polymorphism of human acetyltransferases.Semantic proximity Read ↗

Arylamine N-acetyltransferase 1 (NAT1) genotypes in a Lebanese population.Semantic proximity Read ↗

Functional characterization of nucleotide polymorphisms in the coding region of N-acetyltransferase 1.Semantic proximity Read ↗

Effect of nucleotide substitutions in N-acetyltransferase-1 on N-acetylation (deactivation) and O-acetylation (activation) of arylamine carcinogens: implications for cancer predisposition.Semantic proximity Read ↗

Pharmacogenetics, Regulation and Structural Properties of the Drugmetabolizing Enzymes Arylamine N-acetyltransferases.Semantic proximity Read ↗

Pharmacogenetics of the arylamine N-acetyltransferases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.