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Article

Polymorphisms of human N-acetyltransferases and cancer risk.

Current drug metabolism - 1 Jul 2008

Agúndez José A G

Abstract excerpt

Human arylamine N-acetyltransferases (CoASAc; NAT, EC 2.3.1.5) NAT1 and NAT2 play a key role in the metabolism of drugs and environmental chemicals and in the metabolic activation and detoxification of procarcinogens. Phenotyping analyses have revealed an association between NAT enzyme activities and the risk of developing several forms of cancer. As genotyping procedures have become available for NAT1 and NAT2...

Topics

Acetyltransferases
Animals
Gene Frequency
Genetic Variation
Humans
Neoplasms
Polymorphism, Genetic
Risk

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18680472
DOI: 10.2174/138920008784892083

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18680472-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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