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Article

Autolytic activation of calpain 3 proteinase is facilitated by calmodulin protein.

The Journal of biological chemistry - 9 Jan 2015

Ermolova Natalia, Kramerova Irina, Spencer Melissa J

Abstract excerpt

Calpains are broadly distributed, calcium-dependent enzymes that induce limited proteolysis in a wide range of substrates. Mutations in the gene encoding the muscle-specific family member calpain 3 (CAPN3) underlie limb-girdle muscular dystrophy 2A. We have shown previously that CAPN3 knockout muscles exhibit attenuated calcium release, reduced calmodulin kinase (CaMKII) signaling, and impaired muscle adaptation...

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Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Skeletal

Share to Muscular Dystrophies, Limb-Girdle

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Source

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Identifiers

PMID: 25389288
DOI: 10.1074/jbc.M114.588780
PMCID: PMC4294526

Genes

CAPN3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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