Article
Manipulation of androgens and alterations in the androgen receptor axis in prostate cancer.
Minerva urologica e nefrologica = The Italian journal of urology and nephrology - 1 Mar 2008
Nguyen M M, Wang Z
Abstract excerpt
Androgens play a key role in prostate cancer (PCa) development and progression. For decades, androgen deprivation therapy (ADT) has been the primary treatment for men with metastatic prostate cancer. ADT initially results in the regression of prostate cancers, however, this effect is limited and patients inevitably develop an androgen refractory form of the disease. Many studies have implicated the androgen...
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