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Article

Pattern of somatic androgen receptor gene mutations in patients with hormone-refractory prostate cancer.

Laboratory investigation; a journal of technical methods and pathology - 1 Nov 2002

Hyytinen Eija-R, Haapala Kyllikki, Thompson James, Lappalainen Ilkka, Roiha Mikko, Rantala Immo, Helin Heikki J, Jänne Olli A, Vihinen Mauno, Palvimo Jorma J, Koivisto Pasi A

Abstract excerpt

Progression to hormone-refractory growth of prostate cancer has been suggested to be mediated by androgen receptor (AR) gene alterations. We analyzed AR for mutations and amplifications in 21 locally recurrent prostate carcinomas treated with orchiectomy, estrogens, or a combination of orchiectomy and estramustine phosphate using fluorescence in situ hybridization, single-strand conformation polymorphism, and DNA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12429819
DOI: 10.1097/01.lab.0000038924.67707.75

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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