Article
Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Jul 2003
Taplin Mary-Ellen, Rajeshkumar Barur, Halabi Susan, Werner Cary P, Woda Bruce A, Picus Joel, Stadler Walter, Hayes Daniel F, Kantoff Philip W, Vogelzang Nicholas J, Small Eric J
Abstract excerpt
PURPOSE: The mechanisms responsible for prostate cancer androgen independence are diverse. Mutations of the androgen receptor (AR) gene that broaden ligand specificity have been implicated. Bone marrow specimens containing prostate tumor were obtained from men undergoing antiandrogen withdrawal for AR sequence analysis and clinical correlation. MATERIALS AND METHODS: Eligible men enrolled on a trial of...
Topics
- Adenocarcinoma
- Aged
- Androgen Antagonists
- Base Sequence
- Biomarkers, Tumor
- Biopsy, Needle
- Bone Marrow
- Confidence Intervals
- DNA, Neoplasm
- Humans