Article
Molecular screening of multifocal transitional cell carcinoma of the bladder using p53 mutations as biomarkers.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 1996
Xu X, Stower M J, Reid I N, Garner R C, Burns P A
Abstract excerpt
Thirteen of 28 patients (46%) with grade 2-3 multifocal transitional cell carcinoma (TCC) of the bladder were found to have p53 mutations using DNA sequence analysis. These were subsequently utilized as tumor-specific biomarkers. Analysis of 17 episodes of recurrence from five of the patients rev...
Topics
- Biomarkers
- Carcinoma, Transitional Cell
- DNA Mutational Analysis
- DNA, Neoplasm
- Genes, p53
- Humans
- Mutation
- Neoplasm Recurrence, Local
- Urinary Bladder Neoplasms
