Article
Molecular screening of multifocal transitional cell carcinoma of the bladder using p53 mutations as biomarkers.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 1996
Xu X, Stower M J, Reid I N, Garner R C, Burns P A
Abstract excerpt
Thirteen of 28 patients (46%) with grade 2-3 multifocal transitional cell carcinoma (TCC) of the bladder were found to have p53 mutations using DNA sequence analysis. These were subsequently utilized as tumor-specific biomarkers. Analysis of 17 episodes of recurrence from five of the patients revealed that all but one carried the identical mutation to the primary tumor. Thirty urine samples were collected, at...
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