Article
Molecular profiling of bladder tumors based on the detection of FGFR3 and TP53 mutations.
The Journal of urology - 1 Dec 2006
Lamy A, Gobet F, Laurent M, Blanchard F, Varin C, Moulin C, Andreou A, Frebourg T, Pfister C
Abstract excerpt
PURPOSE: On a routine basis we performed systematic molecular screening for FGFR3 and TP53 mutations in 121 bladder tumors. We then specifically analyzed the predictive value of the recurrence of FGFR3 and TP53 genotypes in superficial lesions. MATERIALS AND METHODS: The FGFR3 gene was analyzed by direct sequencing of exons 7, 10 and 15, whereas TP53 status was determined using the p53 functional assay in yeast....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.