Article
FGFR3 and Tp53 mutations in T1G3 transitional bladder carcinomas: independent distribution and lack of association with prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2005
Hernández Silvia, López-Knowles Elena, Lloreta Josep, Kogevinas Manolis, Jaramillo Roberto, Amorós Alex, Tardón Adonina, García-Closas Reina, Serra Consol, Carrato Alfredo, Malats Núria, Real Francisco X
Abstract excerpt
FGFR3 and Tp53 mutations have been proposed as defining two alternative pathways in the pathogenesis of transitional bladder cancer. FGFR3 mutations are associated with low-grade tumors and a favorable prognosis. Tp53 alterations are associated with advanced tumors and, possibly, with a poor prognosis. We focus here on the subgroup of T1G3 superficial tumors because they are a major clinical challenge. Patients...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.