Article
Genetic alterations in tp53 in recurrent urothelial cancer: a longitudinal study.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2001
Dalbagni G, Ren Z P, Herr H, Cordon-Cardo C, Reuter V
Abstract excerpt
PURPOSE: Because bladder cancer has a recurrence rate that can be as high as 90% at 2 years, we sought to clarify whether these metachronous tumors are polyclonal or monoclonal in origin. We have examined the genetic alterations of the TP53 gene in a cohort of patients with urothelial cancer who underwent multiple biopsies at different times and sites because of tumor recurrence and/or progression. We postulated...
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