Article
The biological action of cDNAs from mutated estrogen receptors transfected into breast cancer cells.
Cancer letters - 23 Mar 1995
Catherino W H, Jordan V C
Abstract excerpt
While tamoxifen may inhibit breast cancer proliferation, mutations in the estrogen receptor could potentially result in breast cancer cells which can circumvent the tamoxifen blockade. Previously, we identified a mutation at codon 351 in the estrogen receptor from a tamoxifen-stimulated human bre...
Topics
- Amino Acid Sequence
- Base Sequence
- Breast Neoplasms
- DNA, Complementary
- Molecular Sequence Data
- Mutation
- Plasmids
- Receptors, Estrogen
- Tamoxifen
- Transfection
- Tumor Cells, Cultured