Article
The biological action of cDNAs from mutated estrogen receptors transfected into breast cancer cells.
Cancer letters - 23 Mar 1995
Catherino W H, Jordan V C
Abstract excerpt
While tamoxifen may inhibit breast cancer proliferation, mutations in the estrogen receptor could potentially result in breast cancer cells which can circumvent the tamoxifen blockade. Previously, we identified a mutation at codon 351 in the estrogen receptor from a tamoxifen-stimulated human breast cancer. This receptor was stably transfected into the estrogen receptor-negative human breast cancer cell line...
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