Article
Repression of endogenous estrogen receptor activity in MCF-7 human breast cancer cells by dominant negative estrogen receptors.
Endocrinology - 1 Aug 1995
Ince B A, Schodin D J, Shapiro D J, Katzenellenbogen B S
Abstract excerpt
We have investigated the ability of several transcriptionally inactive estrogen receptor (ER) mutants to block endogenous ER-mediated transcription in MCF-7 human breast cancer cells. In transient transfections of MCF-7 cells, two of the mutants, a frame-shifted ER (S554fs) and a point-mutated ER...
Topics
- Breast Neoplasms
- Cyclic AMP
- Estradiol
- Frameshift Mutation
- Gene Deletion
- Genes, Dominant
- Humans
- Intracellular Membranes
- Phenotype
- Point Mutation
- Receptors, Estrogen
- Tamoxifen
- Transcription, Genetic
- Transcriptional Activation
- Tumor Cells, Cultured