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Article

Both estradiol and tamoxifen decrease proliferation and invasiveness of cancer cells transfected with a mutated estrogen receptor.

The Journal of steroid biochemistry and molecular biology - 1 Apr 1997

Garcia M, Derocq D, Platet N, Bonnet S, Brouillet J P, Touitou I, Rochefort H

Abstract excerpt

Previous studies have shown that, after wild-type estrogen receptor (ER) transfection in ER-negative breast cancer cells, estradiol but not tamoxifen prevents growth, invasiveness and metastasis of these cells in mice. Because an ER mutation at position 400 converts the triphenylethylene antiestr...

Topics

Animals
Cell Division
Estradiol
Estrogen Antagonists
Mice
Mice, Inbred BALB C
Mice, Nude
Mutation
Neoplasm Invasiveness
Neoplasms, Experimental
Polyunsaturated Alkamides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Receptors, Estrogen

Tamoxifen

Transfection

Source

Identifiers

PMID: 9328205
DOI: 10.1016/s0960-0760(96)00255-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9328205-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Both estradiol and tamoxifen decrease proliferation and invasiveness of cancer cells transfected with a mutated estrogen receptor.PMID 9328205Read ↗

Transfection of human estrogen receptor (ER) cDNA into ER-negative mammalian cell lines.Semantic proximity Read ↗

Differential positive and negative transcriptional regulation by tamoxifen.Semantic proximity Read ↗

Antiestrogens activate an estrogen receptor mutant exhibiting enhanced binding to the estrogen response element.Semantic proximity Read ↗

Different estrogen receptor structural domains are required for estrogen- and tamoxifen-dependent anti-proliferative activity in human mammary epithelial cells expressing an exogenous estrogen receptor.Semantic proximity Read ↗

Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor.Semantic proximity Read ↗

The biological action of cDNAs from mutated estrogen receptors transfected into breast cancer cells.Semantic proximity Read ↗

Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells.Semantic proximity Read ↗

Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice.Semantic proximity Read ↗

The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain.Semantic proximity Read ↗

The role of estrogen receptor mutations in tamoxifen-stimulated breast cancer.Semantic proximity Read ↗

Repression of endogenous estrogen receptor activity in MCF-7 human breast cancer cells by dominant negative estrogen receptors.Semantic proximity Read ↗

Activation of transcriptionally inactive human estrogen receptors by cyclic adenosine 3',5'-monophosphate and ligands including antiestrogens.Semantic proximity Read ↗

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