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Article

Both estradiol and tamoxifen decrease proliferation and invasiveness of cancer cells transfected with a mutated estrogen receptor.

The Journal of steroid biochemistry and molecular biology - 1 Apr 1997

Garcia M, Derocq D, Platet N, Bonnet S, Brouillet J P, Touitou I, Rochefort H

Abstract excerpt

Previous studies have shown that, after wild-type estrogen receptor (ER) transfection in ER-negative breast cancer cells, estradiol but not tamoxifen prevents growth, invasiveness and metastasis of these cells in mice. Because an ER mutation at position 400 converts the triphenylethylene antiestrogen, OH-tamoxifen into a full estrogen agonist, we transfected this mutated form of human ER in an ER-negative rat...

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Identifiers

PMID: 9328205
DOI: 10.1016/s0960-0760(96)00255-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Both estradiol and tamoxifen decrease proliferation and invasiveness of cancer cells transfected with a mutated estrogen receptor.PMID 9328205Read ↗

Transfection of human estrogen receptor (ER) cDNA into ER-negative mammalian cell lines.Semantic proximity Read ↗

Differential positive and negative transcriptional regulation by tamoxifen.Semantic proximity Read ↗

Antiestrogens activate an estrogen receptor mutant exhibiting enhanced binding to the estrogen response element.Semantic proximity Read ↗

Different estrogen receptor structural domains are required for estrogen- and tamoxifen-dependent anti-proliferative activity in human mammary epithelial cells expressing an exogenous estrogen receptor.Semantic proximity Read ↗

Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor.Semantic proximity Read ↗

The biological action of cDNAs from mutated estrogen receptors transfected into breast cancer cells.Semantic proximity Read ↗

Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells.Semantic proximity Read ↗

Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice.Semantic proximity Read ↗

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The role of estrogen receptor mutations in tamoxifen-stimulated breast cancer.Semantic proximity Read ↗

Repression of endogenous estrogen receptor activity in MCF-7 human breast cancer cells by dominant negative estrogen receptors.Semantic proximity Read ↗

Activation of transcriptionally inactive human estrogen receptors by cyclic adenosine 3',5'-monophosphate and ligands including antiestrogens.Semantic proximity Read ↗

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