Article
Molecular basis of transmembrane beta-barrel formation of staphylococcal pore-forming toxins.
Nature communications - 29 Sept 2014
Yamashita Daichi, Sugawara Takaki, Takeshita Miyu, Kaneko Jun, Kamio Yoshiyuki, Tanaka Isao, Tanaka Yoshikazu, Yao Min
Abstract excerpt
Pathogenic bacteria secrete pore-forming toxins (PFTs) to attack target cells. PFTs are expressed as water-soluble monomeric proteins, which oligomerize into nonlytic prepore intermediates on the target cell membrane before forming membrane-spanning pores. Despite a wealth of biochemical data, the lack of high-resolution prepore structural information has hampered understanding of the β-barrel formation process....
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